Quick answer: Rejuran microneedling, often called the salmon DNA facial, combines microneedling with Rejuran Healing Essence, a serum of salmon-derived polynucleotides (PDRN). The microneedling opens tiny channels so the essence can absorb more effectively and support repair, hydration and glow. Expect numbing first, redness for 24 to 48 hours afterward and results that build over a series. At JLoo Beauty Experts in Midtown Manhattan, it is $650 for first-time clients (usual price $950).
"Salmon DNA facial" is the popular name for skin treatments that use polynucleotides, purified DNA fragments derived from salmon. You may also see it called a salmon sperm facial, PDRN facial or PN treatment. The idea comes from Korean dermatology, where polynucleotides have been used for years to support skin repair and hydration.
Rejuran is the best-known polynucleotide brand. It comes in more than one form, and this is where people get confused:
It pairs two things that each help the skin, and work better together.
Microneedling uses very fine, sterile needles to create controlled micro-channels in the skin. That alone prompts your skin's healing response and new collagen and elastin.
Rejuran Healing Essence is applied during the treatment. The micro-channels allow the essence to absorb more effectively than it could on intact skin, sending regenerative signals that help the skin repair, rebuild and glow from within.
The result is a treatment aimed at overall skin quality. It does not add volume, freeze movement or resurface aggressively. It helps skin behave like healthier skin.
It is a good match if your concerns are about skin quality:
It is not the right tool for everything. Deep folds and lost volume call for other treatments, and sagging along the jawline or neck is better addressed by a lifting treatment such as Ultherapy PRIME. Under-eye hollows are a separate conversation; see our guide to under-eye treatments in NYC.
Tell your provider if you have a fish or seafood allergy, since Rejuran is derived from salmon. We also do not treat during pregnancy or breastfeeding, or over an active breakout, cold sore or skin infection.
Your provider will give you instructions for your skin. In general:
Downtime is light, and it helps to know what is normal.
| When | What to expect | What to do |
|---|---|---|
| Day of treatment | Redness and warmth, similar to a mild sunburn. Skin may feel tight. | Keep skin clean. No makeup, exercise, sauna or alcohol. |
| Days 1 to 2 | Pinkness fades. Skin can feel dry or tight. | Gentle cleanser, bland moisturizer and SPF. Makeup is usually fine after 24 hours. |
| Days 3 to 5 | Possible light flaking as skin renews. Glow starts to show. | Keep moisturizing. Do not pick or scrub. |
| Day 7 onward | Skin looks smoother and more luminous. | Return to your normal routine, including retinoids, when your provider says so. |
Avoid direct sun and wear SPF daily while your skin heals. If you notice anything that worries you, such as increasing redness, swelling or pain, contact us.
Most clients notice a healthy glow within the first week. The deeper changes, such as smoother texture and firmer, more hydrated skin, build over several weeks as collagen forms.
One session gives a visible boost. A series gives a lasting change. Microneedling treatments are usually done in a series spaced 4 to 6 weeks apart, and your provider will recommend the number that fits your skin and your goals.
| Rejuran microneedling | PRF microneedling (Glass Skin Facial) | Rejuran I injections | |
|---|---|---|---|
| Active ingredient | Salmon-derived PDRN | Platelet-rich fibrin from your own blood | Salmon-derived PDRN |
| Area | Full face | Full face | Under-eyes |
| Blood draw | No | Yes | No |
| Leans toward | Hydration, repair and calm, glowing skin | Collagen stimulation, texture and scars | Thin, crepey, dehydrated under-eye skin |
| Downtime | Redness for 24 to 48 hours | Redness for 24 to 48 hours | Small bumps or bruising possible for 1 to 3 days |
There is no single winner. Rejuran microneedling suits skin that needs hydration and repair. PRF Microneedling uses your own growth factors and leans toward collagen and texture. The two can also be combined in one plan.
At JLoo Beauty Experts, microneedling with Rejuran Healing Essence is $650 for first-time clients. The usual price is $950 per session. The cost of your consultation goes toward your treatment, and Cherry Pay financing is available. See all options on our Rejuran page.
Salmon DNA facial is a general name for polynucleotide treatments. Rejuran is the best-known brand. At JLoo Beauty Experts, the salmon DNA facial is microneedling with Rejuran Healing Essence.
Numbing cream is applied beforehand, so most clients feel mild pressure or warmth instead of pain.
Expect redness and tightness for 24 to 48 hours, sometimes with light flaking a few days later. Most clients go back to normal activities the next day.
Skip makeup on the day of treatment. It is usually fine after 24 hours, once the micro-channels have closed.
It is often chosen for dry or sensitive skin because it focuses on hydration and repair. Your provider reviews your medical history and skin at your consultation to confirm it suits you.
Yes. Common pairings are PRF Microneedling for collagen, Rejuran I or PRF EzGel for the under-eye area and Ultherapy PRIME for lifting. Your provider will space them properly.
JLoo Beauty Experts is at 505 8th Ave, Suite 23-03, steps from Penn Station and a short walk from Hudson Yards and Herald Square. Explore Rejuran treatments and pricing, or book a consultation and we will build a plan around your skin.
Medically reviewed by Joanne Loo, MS, AGPCNP-BC, Medical Director. MD oversight: Dr. Jade Hon, MD. This article is for educational purposes and is not a substitute for a personalized clinical assessment.
